Dr. Daniel Calame

Daniel Calame, MD, PhD is a physician scientist specialized in rare neurogenetic conditions. Dr. Calame completed clinical training in pediatric neurology at Texas Children's Hospital and postdoctoral research training in human genetics at Baylor College of Medicine (BCM) in the laboratory of Prof. James R. Lupski in 2021. Dr. Calame has since helped direct the BCM-GREGoR (Genomics Research to Elucidate the Genetics of Rare diseases) research center, a part of the National Human Genome Research Institute's GREGoR Consortium. The GREGoR Consortium seeks to use cutting-edge genomic technologies like short and long-read whole genome sequencing, optical genome mapping, and transcriptomics to discover the causes of currently unexplained rare genetic disorders. Dr. Calame has contributed to discovery of dozens of rare genetic disorders including NSRP1-related cerebral palsy, ENTPD1-related hereditary spastic paraplegia, DHX9-related neurodevelopmental disorders, and FLVCR1-related developmental and neurodegenerative disorders.